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Engineering Custom Cooling Component on 3D Bioprinter
3D bioprinting is a state of the art additive manufacturing technique that has revolutionized tissue engineering strategies. The goal of this project is to design a cooling device able to create a stable printing environment to improve current printing capabilities.
Extrusion bioprinting is a method of 3D printing used to create cellularized constructs by laying down materials layer by layer. Specifically, the Cellink Inkredible+ bioprinter works by extruding a bioink from a syringe using pneumatic pressure and collecting the filament on a stage. Once extruded, the bioinks need to be rapidly cooled to keep the shape of the constructs. Bioinks are specialized hydrogels designed to enable 3D printing of microscale scaffolds. These specialized materials are bioprinted to create a biomimetic dynamic microenvironment providing a novel framework to model disease and study pharmacological therapies. However, bioinks are temperature sensitive, each ink is associated with a specific gelation temperature below which it is viscous yet printable and above which it melts. During this project, you will design a custom made temperature control device able to maintain a stable controllable environment for our Cellink Inkredible+ bioprinter in order to print cellular constructs for bone models.
Extrusion bioprinting is a method of 3D printing used to create cellularized constructs by laying down materials layer by layer. Specifically, the Cellink Inkredible+ bioprinter works by extruding a bioink from a syringe using pneumatic pressure and collecting the filament on a stage. Once extruded, the bioinks need to be rapidly cooled to keep the shape of the constructs. Bioinks are specialized hydrogels designed to enable 3D printing of microscale scaffolds. These specialized materials are bioprinted to create a biomimetic dynamic microenvironment providing a novel framework to model disease and study pharmacological therapies. However, bioinks are temperature sensitive, each ink is associated with a specific gelation temperature below which it is viscous yet printable and above which it melts. During this project, you will design a custom made temperature control device able to maintain a stable controllable environment for our Cellink Inkredible+ bioprinter in order to print cellular constructs for bone models.
The goal of this project is to design a device able to create a stable printing environment to improve current printing capabilities. By maintaining a constant temperature the microscale 3D printed constructs will have more consistent morphologies, enabling the creation of biomimetic models to study bone disease. The project will likely involve the design and assembly of cooler modules to provide direct contact cooling to the bioprinter stage and bioink cartridge.
The goal of this project is to design a device able to create a stable printing environment to improve current printing capabilities. By maintaining a constant temperature the microscale 3D printed constructs will have more consistent morphologies, enabling the creation of biomimetic models to study bone disease. The project will likely involve the design and assembly of cooler modules to provide direct contact cooling to the bioprinter stage and bioink cartridge.
Anke de Leeuw (adeleeuw@ethz.ch), Institute for Biomechanics, ETH Zürich Office address: HCP 18.1, Professorship: Ralph Müller
Anke de Leeuw (adeleeuw@ethz.ch), Institute for Biomechanics, ETH Zürich Office address: HCP 18.1, Professorship: Ralph Müller