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Computational analysis of mechanical strains in animal models of adaptation and regeneration
A number of mouse loading models exist to study bone adaptation and regeneration. However, the loading conditions and strains that act on bones vary between the models. The aim of this project is to compare the loading parameters and the strain distribution in two animal models by means of FEA.
Keywords: bone adaptation, bone regeneration, mouse loading models, finite element analysis
Numerous animal loading models exist to study the effect of mechanical loading on bone remodelling and regeneration. In particular, we have established two distinct mouse models for cyclic loading of 1) the sixth caudal vertebra (adaptation) and 2) the fractured femur (regeneration). The structural changes within the loaded limb can then be tracked in vivo by means of time-lapsed micro-CT imaging. However, the strains that are engendered throughout the loaded limbs have not yet been characterized.
The aim of this project is therefore to analyse the loading protocols for both the vertebra and the femur models, and then to perform micro-FE simulation using these boundary conditions. Once these loading conditions are applied, the distribution and nature of the strains between the two models will be compared and evaluated.
Tasks: 80% computational, 20 % data analysis
Numerous animal loading models exist to study the effect of mechanical loading on bone remodelling and regeneration. In particular, we have established two distinct mouse models for cyclic loading of 1) the sixth caudal vertebra (adaptation) and 2) the fractured femur (regeneration). The structural changes within the loaded limb can then be tracked in vivo by means of time-lapsed micro-CT imaging. However, the strains that are engendered throughout the loaded limbs have not yet been characterized.
The aim of this project is therefore to analyse the loading protocols for both the vertebra and the femur models, and then to perform micro-FE simulation using these boundary conditions. Once these loading conditions are applied, the distribution and nature of the strains between the two models will be compared and evaluated.
Tasks: 80% computational, 20 % data analysis
The aim of this project is the assessment of loading conditions on the vertebra and femur model. Finite element analysis will then be used to apply the loading conditions from our cyclical loading regimes in each model. Finally, both the loading condition- and finite element results will be assessed via a range of relevant mechanical parameters, and the vertebra and femur models compared.
The aim of this project is the assessment of loading conditions on the vertebra and femur model. Finite element analysis will then be used to apply the loading conditions from our cyclical loading regimes in each model. Finally, both the loading condition- and finite element results will be assessed via a range of relevant mechanical parameters, and the vertebra and femur models compared.
Ariane Scheuren (arianesc@hest.ethz.ch) and Graeme Paul (graeme.paul@hest.ethz.ch), Institute for Biomechanics, ETH Zürich, Professorship Ralph Müller
Ariane Scheuren (arianesc@hest.ethz.ch) and Graeme Paul (graeme.paul@hest.ethz.ch), Institute for Biomechanics, ETH Zürich, Professorship Ralph Müller