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Computational Analysis and Optimization of Loading Scenarios for Scaffold-Mechanostimulation
Scaffolds with show huge potential to improve fracture healing by enabling bone mineralization through appropriate structure and mechanical properties. Bone mineralization can be even enhanced through mechanical loading.
Keywords: computational modeling, FE Analysis, scaffolds, tissue engineering, mechanical loading
Engineered bone-like tissue scaffolds with appropriate mechanical properties for bone healing are sought to treat challenging fractures. It is known, that cells react to mechanostimuli and thus mechanical loading is applied to increase bone mineralization. So far, different compressive loading cycles have been applied to enhance bone mineralization, but it has not yet been sufficiently investigated which effects different loading scenarios have. To further increase bone mineralization, better insights into the effects of different mechanical load application in terms of stress and strain inducement as well as the effects on the bone mineralization are substantial.
Engineered bone-like tissue scaffolds with appropriate mechanical properties for bone healing are sought to treat challenging fractures. It is known, that cells react to mechanostimuli and thus mechanical loading is applied to increase bone mineralization. So far, different compressive loading cycles have been applied to enhance bone mineralization, but it has not yet been sufficiently investigated which effects different loading scenarios have. To further increase bone mineralization, better insights into the effects of different mechanical load application in terms of stress and strain inducement as well as the effects on the bone mineralization are substantial.
The Goal is to investigate different mechanical loading scenarios using computational methods and to gain further insights into their effects. Specifically FE Analyses should be computed for different promising loading scenarios to investigate the strain and stress distribution using CT images of cell-seeded scaffolds.
The Goal is to investigate different mechanical loading scenarios using computational methods and to gain further insights into their effects. Specifically FE Analyses should be computed for different promising loading scenarios to investigate the strain and stress distribution using CT images of cell-seeded scaffolds.
Julia Griesbach (julia.griesbach@hest.ethz.ch), Institute for Biomechanics, ETH Zurich, Professorship Ralph Müller
Julia Griesbach (julia.griesbach@hest.ethz.ch), Institute for Biomechanics, ETH Zurich, Professorship Ralph Müller