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Master Project in Cancer Systems Biology
We are looking for a passionate master student to investigate the tumor microenvironment of human breast cancers. You will implement a novel mass cytometry (CyTOF) technique, called imaging mass cytometry.
Keywords: cancer systems biology, imaging, mass cytometry, tumor microenvironment, signaling, single-cell analysis, laser ablation, pathology
A master student position in the group of Prof. Bernd Bodenmiller is available at the University of Zurich, Institute of Molecular Life Sciences.
You will implement a novel mass cytometry (CyTOF) technique, called imaging mass cytometry, which uniquely enables the visualization of up to 100 cell phenotypes, proteins, and phosphorylation sites.
Breast cancer is the most commonly diagnosed cancer in women, and causes annually 450,000 deaths worldwide. An important role in tumor progression has been allocated to the tumor microenvironment, which can exhibit an inflammatory and hypoxic environment. These effects, amongst others, can have a strong impact on tumor cells and ultimately support metastasis, and confer drug resistance during cancer therapy.
In order to comprehensively capture a complex disease microenvironment, you will exploit imaging mass cytometry. Mass cytometry provides high-dimensional analysis of cell type and state at single-cell resolution. A novel imaging approach enables the simultaneous visualization of up to 100 markers on a single tissue section. Imaging mass cytometry provides comprehensive analysis of adherent cells, frozen tissues, and formalin-¬fixed paraffin-embedded (FFPE) samples. As such it has the potential to yield novel insights from existing large collections of FFPE tumor samples and associated clinical information.
A master student position in the group of Prof. Bernd Bodenmiller is available at the University of Zurich, Institute of Molecular Life Sciences.
You will implement a novel mass cytometry (CyTOF) technique, called imaging mass cytometry, which uniquely enables the visualization of up to 100 cell phenotypes, proteins, and phosphorylation sites.
Breast cancer is the most commonly diagnosed cancer in women, and causes annually 450,000 deaths worldwide. An important role in tumor progression has been allocated to the tumor microenvironment, which can exhibit an inflammatory and hypoxic environment. These effects, amongst others, can have a strong impact on tumor cells and ultimately support metastasis, and confer drug resistance during cancer therapy.
In order to comprehensively capture a complex disease microenvironment, you will exploit imaging mass cytometry. Mass cytometry provides high-dimensional analysis of cell type and state at single-cell resolution. A novel imaging approach enables the simultaneous visualization of up to 100 markers on a single tissue section. Imaging mass cytometry provides comprehensive analysis of adherent cells, frozen tissues, and formalin-¬fixed paraffin-embedded (FFPE) samples. As such it has the potential to yield novel insights from existing large collections of FFPE tumor samples and associated clinical information.
You will ultimately map signaling, cell phenotypes and their interactions in the breast cancer tumor microenvironment.
You will ultimately map signaling, cell phenotypes and their interactions in the breast cancer tumor microenvironment.
Highly motivated master students with a background in cancer systems biology please contact Bernd Bodenmiller (bernd.bodenmiller@imls.uzh.ch) and Charlotte Giesen (charlotte.giesen@uzh.ch).
Highly motivated master students with a background in cancer systems biology please contact Bernd Bodenmiller (bernd.bodenmiller@imls.uzh.ch) and Charlotte Giesen (charlotte.giesen@uzh.ch).