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Interferometric imager with subnanometer-resolution for point-of-care diagnosis
This project is about developing and verifying a prototype of an imaging device (based on CMOS) for point-of-care (PoC) applications (such as early state detection of blood infections (SEPSIS) and other diseases).
Imaging surfaces with nano-scale topology is essential for the field of nanosciences, in particular for material analysis and medical applications. To-date such imaging devices are often very expensive, bulky and mostly for laboratory usage. This project is about developing and verifying a prototype of such an imaging device (based on CMOS) for point-of-care (PoC) applications (such as early state detection of blood infections (SEPSIS) and other diseases). The detection mechanism is based on a lens-free interferometric method allowing the detection of height-differences down a few Å over an area of ~1cm2. This will allow the real-time reading of millions of biomarkers at once. The small size (handheld) and low-cost (based on consumer electronics) of the device will allow PoC in remote and poor areas for endconsumer applications.
A first prototype was successfully tested within an EU project (RAIS). The project could include the following parts:
• Development of handheld imaging device with smart-phone control (including improvement of optical setup)
• Evaluating Point-of-care (PoC) applications with protein-protein interaction (could be done in collaboration with other institutions or local hospitals)
• Development of microfluidic chip (microarray deposition and cartridge design)
• Development and implementation of the holographic tomography software for 3D micro-array
• Using quantum sources and single-photon detectors to increase sensitivity and develop first practical quantum device for imaging (part of EU project)
The student would learn to build an optical interferometer (including the fields of optics, programing, electronics), design a Point-of-Care / Internet-of-Things prototype, exploit and perform biomedical measurements, design & verify computational holography including machine learning and develop practical quantum imaging device. The exact project can be adapted to the interest of the student and his availability.
The work will be carried at ICFO, ands its state-of-the-art laboratories (located close to Barcelona) under the supervision and support of ICFO engineers, technicians and PhD students. Do not hesitate to contact us for more information or a lab-tour.
Location:
ICFO – The Institute of Photonic Sciences is a non-profit research organization performing applied research in collaboration with several companies of the region. The Optoelectronics group at ICFO, led by Prof. Valerio Pruneri, aims at bridging the academic and industrial worlds by pursuing fundamental ideas with great potential for revolutionizing future photonic products. Valerio Pruneri himself is a highly recognized scientist in the field (>250 publications, >40 patents) with a wide and collaborative network of industrial partners.
Imaging surfaces with nano-scale topology is essential for the field of nanosciences, in particular for material analysis and medical applications. To-date such imaging devices are often very expensive, bulky and mostly for laboratory usage. This project is about developing and verifying a prototype of such an imaging device (based on CMOS) for point-of-care (PoC) applications (such as early state detection of blood infections (SEPSIS) and other diseases). The detection mechanism is based on a lens-free interferometric method allowing the detection of height-differences down a few Å over an area of ~1cm2. This will allow the real-time reading of millions of biomarkers at once. The small size (handheld) and low-cost (based on consumer electronics) of the device will allow PoC in remote and poor areas for endconsumer applications. A first prototype was successfully tested within an EU project (RAIS). The project could include the following parts: • Development of handheld imaging device with smart-phone control (including improvement of optical setup) • Evaluating Point-of-care (PoC) applications with protein-protein interaction (could be done in collaboration with other institutions or local hospitals) • Development of microfluidic chip (microarray deposition and cartridge design) • Development and implementation of the holographic tomography software for 3D micro-array • Using quantum sources and single-photon detectors to increase sensitivity and develop first practical quantum device for imaging (part of EU project) The student would learn to build an optical interferometer (including the fields of optics, programing, electronics), design a Point-of-Care / Internet-of-Things prototype, exploit and perform biomedical measurements, design & verify computational holography including machine learning and develop practical quantum imaging device. The exact project can be adapted to the interest of the student and his availability. The work will be carried at ICFO, ands its state-of-the-art laboratories (located close to Barcelona) under the supervision and support of ICFO engineers, technicians and PhD students. Do not hesitate to contact us for more information or a lab-tour.
Location: ICFO – The Institute of Photonic Sciences is a non-profit research organization performing applied research in collaboration with several companies of the region. The Optoelectronics group at ICFO, led by Prof. Valerio Pruneri, aims at bridging the academic and industrial worlds by pursuing fundamental ideas with great potential for revolutionizing future photonic products. Valerio Pruneri himself is a highly recognized scientist in the field (>250 publications, >40 patents) with a wide and collaborative network of industrial partners.
The goal of this master-/ or project-thesis is to develop a hand-held version of this device and to test it on real samples.
The goal of this master-/ or project-thesis is to develop a hand-held version of this device and to test it on real samples.