University of ZurichAcronym | UZH | Homepage | http://www.uzh.ch/ | Country | Switzerland | ZIP, City | | Address | | Phone | | Type | Academy | Current organization | University of Zurich | Child organizations | | Members | | Memberships | |
Open OpportunitiesScanning ion conductance microscopy (SICM) is the non-contact SPM technology to image live cells based on glass capillaries with a nanometric aperture. It applies a voltage and measures the ionic current flowing through the pipette above the sample in the buffer solution: the recorded current represents the feedback signal to measure the topography of the sample. In collaboration with Prof. Fantner at EPFL, this project aims to assemble a state of the art high-speed SICM to enable time-resolved live cell imaging. - Biomedical Engineering, Electrical and Electronic Engineering, Mechanical Engineering, Nanotechnology, Signal Processing
- Bachelor Thesis, Course Project, ETH Zurich (ETHZ), Lab Practice, Master Thesis, Summer School
| What about implantable self-powering devices to monitor biophysical signals at nanoscale? As a part of the interdisciplinary frontier between material science and new biomedical applications, being able to monitor biological or physical markers and signals, allows for a better treatment from both the diagnostic and healing point of view. Among them, biocompatible and non-intrusive wearable monitoring devices, which are so flexible to adhere perfectly to biological tissue, and even to cells like neurons, gain increasing interest. However, fabricating the devices and the electrodes at nano/microscale remains a challenge.
FluidFM is a force-controlled nanopipette, a versatile tool also for 2D patterning and 3D printing in liquid environment, opening the opportunity to manufacture the devices at the sub-micron scale.
We are going to create the devices and electrodes depositing conductive polymers with the FluidFM and then to perform the opportune characterization. - Electrical and Electronic Engineering, Materials Engineering, Medical and Health Sciences, Physics
- Master Thesis
| Pemphigus vulgaris (PV) is a unique group of autoimmune diseases. Researches have demonstrated that antibody-induced disruption of Dsg3 transadhesion initiates a signaling response in basal keratinocytes followed by loss of tissue integrity. The complexity of morphogenesis and tissue regeneration implies the existence of a transcellular communication network in which individual cells sense the environment and coordinate their biological activity in time and space.
To understand the fascinating ability of tissue self-organization, comprehensive study of biophysical properties (cell topography and bioelectricity) in combination with the analysis of biochemical networks (signaling pathways and genetic circuits) is required.
Together with the University of Bern and University of Lübeck, we aim to utilize the tools to study the topography and electrophysiology (cell potential, ion channel recording, localized ion detection, charges) of HPEK cells (human primary keratinocytes cells) to unravel the signaling pathways of the disease. We utilize optical imaging (fluorescence dyes) and biosensing tools (including the state of the art hs-SICM and electrical FluidFM setup) to study HPEK cells upon desmosome disruption.
- Biology, Biomedical Engineering, Chemistry, Electrical and Electronic Engineering, Interdisciplinary Engineering, Medical and Health Sciences
- Bachelor Thesis, Lab Practice, Master Thesis, Semester Project, Summer School
| Our aim is to create an autonomous racing system capable of swiftly learning optimal racing strategies and navigating tracks more effectively (faster) than traditional methods and human drivers using RL. - Intelligent Robotics
- Master Thesis, Semester Project
| Use Inverse Reinforcement Learning (IRL) to learn reward functions from previous expert drone demonstrations. - Engineering and Technology, Intelligent Robotics
- Master Thesis, Semester Project
| Explore the use of large vision language models to control a drone. - Engineering and Technology, Intelligent Robotics
- Master Thesis, Semester Project
| Learn complex drone maneuvers from human feedback using Reinforcement Learning (RL). - Engineering and Technology, Intelligent Robotics
- Master Thesis, Semester Project
| The aim of the project is to develop a deep learning model capable of performing 3D semantic segmentation of the different features of the middle ear, from synchrotron-based X-ray microtomography 3D volumes. Challenges include developing a high-performance algorithm for handling large data sizes (20 GB per volume). The project consists in a first phase about dataset generation followed by a second phase of development/selection of the most appropriate DL model and metrics. - Computer Vision, Image Processing, Neural Networks, Genetic Alogrithms and Fuzzy Logic, Otorhinolaryngology
- Collaboration, Master Thesis, Semester Project
| This project aims at developing a machine learning approach (for example, using convolutional neural networks) for localizing and tracking anatomical landmarks from cardiac MR images. - Biomedical Engineering, Electrical and Electronic Engineering
- Master Thesis
| You will develop a diagnostic test for testicular cancer. The focus of the project will be on creating the biochemical protocols for the test. The project is in collaboration with a prelaunch startup and a hospital (USZ). Therefore, it is ideal for motivated students who want to have a direct impact - Analytical Biochemistry, Biological and Medical Chemistry, Biomedical Engineering, Immunological and Bioassay Methods, Interdisciplinary Engineering, Materials Engineering, Sensor (Chemical and Bio-) Technology
- Bachelor Thesis, Internship, Lab Practice, Master Thesis, Semester Project, Summer School
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